Anomalías en centro vasomotor del tronco cerebral en SFC/EM

[elipoarch]

[t]Correlaciones autonómicas anormales con Resonancias Magnéticas en el centro vasomotor del tronco cerebral en el síndrome de fatiga crónica[/t]
Tomando la tensión arterial y el ritmo cardíaco como indicadores de la función autónoma, y relacionándolos con los resultados volumétricos y T1 y T2w, observan que se detectaron regresiones anormales en los núcleos del tronco cerebral del centro vasomotor , la formación reticular del cerebro medio y el hipotálamo , pero también en los núcleos límbicos implicados en las respuestas al estrés y en la sustancia blanca prefrontal. Sin embargo, la comparación entre los grupos de SFC y los controles sanos no encontraron diferencias en la resonancia magnética en estos lugares. El estudio concluye:
"Por consiguiente, proponemos que estos núcleos reguladores están funcionando correctamente, pero que la comunicación bidireccional entre ellos se altera en el SFC y esto afecta a la señalización hacia / desde efectores / sensores periféricos, culminando en las correlaciones inversas o ampliadas. Esta explicación de las diversas correlaciones anormales detectadas aquí consolida la conclusión de un déficit de conducción nerviosa tronco cerebral / cerebro medio deducido anteriormente (Barnden et al . , 2015)."

[t]Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome[/t]

Abstract
Autonomic changes are often associated with the chronic fatigue syndrome (CFS), but their pathogenetic role is unclear and brain imaging investigations are lacking. The vasomotor centre and, through it, nuclei in the midbrain and hypothalamus play a key role in autonomic nervous system regulation of steady state blood pressure (BP) and heart rate (HR). In this exploratory cross-sectional study, BP and HR, as indicators of autonomic function, were correlated with volumetric and T1- and T2-weighted spin-echo (T1w and T2w) brain MRI in 25 CFS subjects and 25 normal controls (NC). Steady state BP (systolic, diastolic and pulse pressure) and HR in two postures were extracted from 24 h blood pressure monitoring. We performed (1) MRI versus autonomic score interaction-with-group regressions to detect locations where regression slopes differed in the CFS and NC groups (collectively indicating abnormality in CFS), and (2) MRI regressions in the CFS and NC groups alone to detect additional locations with abnormal correlations in CFS. Significant CFS regressions were repeated controlling for anxiety and depression (A&D). Abnormal regressions were detected in nuclei of the brainstem vasomotor centre, midbrain reticular formation and hypothalamus, but also in limbic nuclei involved in stress responses and in prefrontal white matter. Group comparisons of CFS and NC did not find MRI differences in these locations. We propose therefore that these regulatory nuclei are functioning correctly, but that two-way communication between them is impaired in CFS and this affects signalling to/from peripheral effectors/sensors, culminating in inverted or magnified correlations. This single explanation for the diverse abnormal correlations detected here consolidates the conclusion for a brainstem/midbrain nerve conduction deficit inferred earlier (Barnden et al., 2015). Strong correlations were also detected in isolated NC regressions.

enlace al estudio: http://www.sciencedirect.com/science/ar ... 8216300584" onclick="window.open(this.href);return false;