Ratones d laboratorio susceptible de ser infectados por XMRV

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[t]Common inbred strains of the laboratory mouse that are susceptible to
infection by mouse xenotropic gammaretroviruses and the human derived
XMRV[/t]
Surendranath Baliji, Qingping Liu, and Christine A. Kozak*
Laboratory of Molecular Microbiology, National Institute of Allergy
and Infectious Diseases Bethesda, MD 20892

* To whom correspondence should be addressed. Email: [email protected].


Abstract
Laboratory mouse strains carry endogenous copies of the xenotropic
leukemia viruses (X-MLVs), named for their inability to infect cells
of the laboratory mouse. This resistance to exogenous infection is due
to a nonpermissive variant of the XPR1 gammaretrovirus receptor, a
resistance that also limits in vivo expression of germline X-MLV
proviruses capable of producing infectious virus. Because laboratory
mice vary widely in their proviral content and in virus expression
pattern, we screened inbred strains for sequence and functional
variants of the XPR1 receptor. We also typed inbred strains and wild
mouse species for an endogenous provirus, Bxv1, that is capable of
producing infectious X-MLV and that also contributes to the generation
of pathogenic recombinant MLVs. We identified the active Bxv1 provirus
in many common inbred strains and in some Japanese M. molossinus mice,
but in none of the other wild mouse species that carry X-MLVs. Our
screening for Xpr1 variants identified the permissive Xpr1sxv allele
in 7 strains of laboratory mice including a Bxv1 positive strain,
F/St, which is characterized by lifelong X-MLV viremia. Cells from
three strains carrying Xpr1sxv, SWR, SJL and SIM.R, were shown to be
infectible by X-MLV and XMRV; these strains carry different alleles at
Fv1 and vary in their sensitivity to specific X/P-MLV isolates and
XMRV. Several strains with Xpr1sxv lack the active Bxv1 provirus or
other endogenous X-MLVs and may provide a useful model system to
evaluate the in vivo spread of these gammaretroviruses and their
disease potential in their natural host.

[elipoarch]

Os pego esto pero estoy de encefalograma plano, así que no he entendido ni papa!!!