Los investigadores quieren probar antiRV en SFC

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[t]Researchers want to test HIV medicine against fatigue syndrome, Dagens Medecin[/t]
per XMRV Global Action el dissabte, 4 / desembre / 2010 a les 08:12

2010-12-02RIKSSTÄMMAN 2010

According to new research may chronic fatigue syndrome caused by a virus. Now want researcher Judy Mikovits test whether the hypothesis is by treating patients with antivirals.Judy Mikovits. Photo: Magnus Gotanda

It was in October 2009 by U.S. researchers showed that patients with the controversial diagnosis of chronic fatigue syndrome, also known as myalgic encephalomyelitis, largely were infected by the human retrovirus XMRV, in contrast to healthy controls.

The study, published in the journal Science, attracted much attention. Among other things, the debate about whether individuals who have the virus should receive donations.

While the findings could not be repeated in several other recent published studies. But that does not mean that there is no connection, according to Judy Mikovits, one of the researchers behind the original study.

─ It requires very sensitive methods to detect XMRV in the blood and in several of the studies in question have only used a single method, while we used more. In addition, there have been so that the patients actually had chronic fatigue syndrome, according to the criteria we used, "said Judy Mikovits at a symposium today at the meeting.

She also referred to a study by another research group, published in the journal PNAS, which found a relatively similar context as her own group did.

─ And, according to preliminary data from a British materials, we see similar results in our original study, "said Judy Mikovits.

During the symposium pointed out, however, Annika Linde, state epidemiologist in the Infectious Diseases Institute, the results so far must be interpreted with caution.

─ Orakssambandet between XMRV and chronic fatigue syndrome is far from clear. It could possibly be that there is disease in itself that activates the virus that may have been sleeping in the genome, and not vice versa. Now we need to include large-scale epidemiological studies to study the spread of the virus, "she said.

Judy Mikovitz and her colleagues hope to start a treatment study of patients with chronic fatigue syndrome who are infected with XMRV. The idea is to use the already approved anti-retroviral drugs against HIV.

─ It is shown in test tube experiments that such drugs can reduce the replication of XMRV, which provides a basis to test it on patients. If this would have an effect on their symptoms, we have indirect evidence of a causal relationship. We are ready to launch a clinical trial, but at present we lack the funding, "said Judy Mikovits Dagens Medicin.

Read also: Retroviruses linked with chronic fatigue syndrome Carl-Magnus Hakecarl-magnus.hake @ dagensmedicin.se


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[EndSFC]

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