Bifidobacterium infantis 35624 reduce inflamación en SFC?

[elipoarch]

Aparentemente, este probiótico, BIFIDOBACTERIUM INFANTIS 35624, redujo los marcadores inflamatorios en SFC, por lo menos en un subgrupo de modo significativo, y de un modo más moderado en los otros. Es una muestra pequeña, aunque se trata de un estudio doble ciego contra placebo, así que es interesante, sobre todo teniendo en cuenta que el sistema inmune depende en gran parte de nuestro intestino. Lo que no comenta el estudio es si esta reducción de marcadores se corresponde con una reducción de síntomas o no... Supongo que tendremos que esperar...

[t]Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut.[/t]
Groeger D, O'Mahony L, Murphy EF, Bourke JF, Dinan TG, Kiely B, Shanahan F, Quigley EM.
Source
Alimentary Health Ltd.; Cork, Ireland.

Abstract
Certain therapeutic microbes, including Bifidobacteria infantis (B. infantis) 35624 exert beneficial immunoregulatory effects by mimicking commensal-immune interactions; however, the value of these effects in patients with non-gastrointestinal inflammatory conditions remains unclear. In this study, we assessed the impact of oral administration of B. infantis 35624, for 6‒8 weeks on inflammatory biomarker and plasma cytokine levels in patients with ulcerative colitis (UC) (n = 22), chronic fatigue syndrome (CFS) (n = 48) and psoriasis (n = 26) in three separate randomized, double-blind, placebo-controlled interventions. Additionally, the effect of B. infantis 35624 on immunological biomarkers in healthy subjects (n = 22) was assessed. At baseline, both gastrointestinal (UC) and non-gastrointestinal (CFS and psoriasis) patients had significantly increased plasma levels of C-reactive protein (CRP) and the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) compared with healthy volunteers. B. infantis 35624 feeding resulted in reduced plasma CRP levels in all three inflammatory disorders compared with placebo. Interestingly, plasma TNF-α was reduced in CFS and psoriasis while IL-6 was reduced in UC and CFS. Furthermore, in healthy subjects, LPS-stimulated TNF-α and IL-6 secretion by peripheral blood mononuclear cells (PBMCs) was significantly reduced in the B. infantis 35624-treated groups compared with placebo following eight weeks of feeding. These results demonstrate the ability of this microbe to reduce systemic pro-inflammatory biomarkers in both gastrointestinal and non-gastrointestinal conditions. In conclusion, these data show that the immunomodulatory effects of the microbiota in humans are not limited to the mucosal immune system but extend to the systemic immune system.

enlace: http://www.ncbi.nlm.nih.gov/pubmed/23842110" onclick="window.open(this.href);return false;

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