Neurotrofina (BDNF) reducida en Síndrome de Fatiga Crónica

[elipoarch]

Un interesante estudio (pequeñito, como siempre) que ha llegado a una conclusión aún más interesante: los niveles de Neurotrofina (BDNF - Factor Neurotrófico Derivado del Cerebro, una proteína que se encarga del crecimiento, mantenimiento y diferenciación de las neuronas así como de sus sinapsis y por tanto de su plasticidad), está prácticamente igual de reducido en el Síndrome de Fatiga Crónica como en la Esclerosis Múltiple.

Puesto que ambas enfermedades tienen síntomas similares y ambas cursan con fatiga intensa, parece lógico que las comparen, y eso ha hecho este estudio. Que los BDNF estaban bajos en la Esclerosis Múltiple ya se sabía, lo que no esperaban es que los resultados en SFC fueran tan similares.

Concluye el estudio diciendo que "este descubrimiento puede reflejar una habilidad reducida de mantener la estructura y función neuronal en los enfermos de SFC. Son necesarios más estudios que evalúen el daño neuronal en los enfermos de SFC"
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[t]Brain Derived Neurotrophic Factor is Decreased in Chronic Fatigue Syndrome and Multiple Sclerosis[/t]
Matthew Sorenson1*, Leonard Jason2, Jonna Peterson3, Joshua Herrington4, and Herbert Mathews5
1School of Nursing, De Paul University, Chicago, USA 2Department of Psychology, De Paul University, Chicago, USA 3Rush University, Chicago, USA 4Florida International University, Florida, USA 5Loyola University Chicago, Chicago, USA


Abstract

Objective: This study examined the levels of a major regulator of neuronal survival, brain derived neurotrophic factor (BDNF) in two populations; individuals with multiple sclerosis and chronic fatigue syndrome. BDNF is a protein involved in the maintenance and maturation of both peripheral and central neurons. In patients with multiple sclerosis, BDNF expression is often decreased and believed to reflect ineffective repair mechanisms. As a preliminary exploration, we examined the production of BDNF on the part of peripheral blood mononuclear cells in three groups: patients with Chronic Fatigue Syndrome (CFS [n=15]), patients with multiple sclerosis (n=57), and a set of putatively healthy controls (n=37).

Methods: Mononuclear cells were extracted from peripheral blood samples and cultured for 48 hours. Production of BDNF was evaluated from phyto-haemagglutinin (PHA) and phorbol-12-myristate-13-acetate (PMA) stimulated and unstimulated cells. BDNF levels were determined using a commercially available enzyme linked immuno absorbent assay (sensitivity: 62.5-4,000 pg/mL).

Results: Both CFS and MS samples displayed nearly identical levels of BDNF, levels that were 25 percent of that displayed by the healthy control sample. For unstimulated cells, the BDNF values were 404.71 pg/ml for the CFS sample, 573.33 pg/ml for the MS sample and ,114.15 pg/ml for the control sample. For stimulated cells, the BDNF values were 442.55 pg/ml for the CFS sample, 367.33 pg/ml for the stimulated MS sample, and 432.24 pg/ml for the stimulated control sample.

Conclusion: The deceased production of BDNF on the part of MS patients is consistent with the literature. However, the decreased production in those with CFS was unexpected and a novel finding. This finding could reflect a reduced ability to maintain neuronal structure and function in those with CFS. Future studies are needed to evaluate for neuronal damage in those with CFS.


enlace al estudio: http://omicsonline.org/open-access/brai ... 12-013.pdf" onclick="window.open(this.href);return false;


Aquí os he puesto el estudio, pero si queréis un análisis profundo, no dejéis de ir a la web de Phoenix Rising, http://www.cortjohnson.org/blog/2014/06 ... ndrome-pt/" onclick="window.open(this.href);return false;. Es largo, pero vale la pena.

[María D]

Interesante, como siempre son todos tus aportes.
Gracias, Eli!

[Ana M]

Muy interesante, gracias