Recopilación de estudios notables en la ME-pedia:
http://me-pedia.org/wiki/Notable_studies" onclick="window.open(this.href);return false;
Notable studies
This page lists published ME/CFS studies that are notable, for particularly interesting findings, for controversial findings, or for their quality or their size.
Epidemiological
2015 Institute of Medicine report Ellen Wright Clayton (Chair), Margarita Alegría, Lucinda Bateman, Lily Chu, Charles S. Cleeland, Ronald Davis, Betty Diamond, Theodore Ganiats, Betsy Keller, Nancy Klimas, A. Martin Lerner, Cynthia Mulrow, Benjamin Natelson, Peter Rowe, Michael Shelanski http://me-pedia.org/wiki/Institute_of_Medicine_report" onclick="window.open(this.href);return false;
2015 Pathways to prevention report Green CR, Cowan P, Elk R, O'Neil KM, Rasmussen AL http://me-pedia.org/wiki/Pathways_to_prevention_report" onclick="window.open(this.href);return false;
2014 Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008–2012 Bakken IJ, Tveito K, Gunnes N, Ghaderi S, Stoltenberg C, Trogstad L, Håberg SE, Magnus P http://www.ncbi.nlm.nih.gov/pubmed/25274261" onclick="window.open(this.href);return false;
2013 The prevalence of chronic fatigue syndrome/myalgic encephalomyelitis: a meta-analysis Samantha Johnston, Ekua Weba Brenu, Donald Staines, Sonya Marshall-Gradisnik http://www.ncbi.nlm.nih.gov/pubmed/23576883" onclick="window.open(this.href);return false;
2011 Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care Luis Nacul, Eliana Lacerda, Derek Pheby, Peter Campion, Mariam Molokhia, Shagufta Fayyaz, Jose CDC Leite, Fiona Poland, Amanda Howe, Maria L Drachler http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170215/" onclick="window.open(this.href);return false;
2007 The burden of disease and injury in Australia 2003 Stephen Begg, Theo Vos, Barker B, Stevenson C, Stanley L, Lopez A http://www.aihw.gov.au/publication-deta ... 6442467990" onclick="window.open(this.href);return false;
2006 Prolonged Illness after infectious mononucleosis is associated with altered immunity but not with increased viral load Cameron, B., Bharadwaj, M., Burrows, J., Fazou, C., Wakefield, D., Hickie, I., Ffrench, R., Khanna, R. and A. Lloyd See also Model of Post Infective Fatigue Forming: the Dubbo Studies http://jid.oxfordjournals.org/content/193/5/664.full" onclick="window.open(this.href);return false;
2006 Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virus Vernon, S., Whistler, T., Cameron, B., Hickie, I., Reeves, W. and A. Lloyd See also Model of Post Infective Fatigue Forming: the Dubbo Studies http://www.ncbi.nlm.nih.gov/pubmed/16448567" onclick="window.open(this.href);return false;
2006 Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study I Hickie, T Davenport, D Wakefield, Vollmer-Conna U, Cameron B, Vernon SD, Reeves WC, Lloyd A http://www.ncbi.nlm.nih.gov/pubmed/16950834" onclick="window.open(this.href);return false;
2005 A systematic review describing the prognosis of chronic fatigue syndrome Ruth Cairns, Matthew Hotopf http://www.ncbi.nlm.nih.gov/pubmed/15699087" onclick="window.open(this.href);return false;
l 1996 Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups Anthony Komaroff, Fagioli LR, Doolittle TH, Gandek B, Gleit MA, Guerriero RT, Kornish RJ 2nd, Ware NC, Ware JE Jr, Bates DW http://www.ncbi.nlm.nih.gov/pubmed/8873490" onclick="window.open(this.href);return false;
Immunological
2015 Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome Landi A, Broadhurst D, Suzanne Vernon, Tyrrell DL, Houghton M http://www.ncbi.nlm.nih.gov/m/pubmed/26615570/" onclick="window.open(this.href);return false;
2015 Distinct plasma immune signatures in ME/CFS are present early in the course of illness Mady Hornig, Jose Montoya, Nancy Klimas, Levine S, Felsenstein D, Lucinda Bateman, Daniel Peterson, Gottschalk CG, Schultz AF, Che X, Eddy ML, Anthony Komaroff, Ian Lipkin http://www.ncbi.nlm.nih.gov/pubmed/?term=26079000" onclick="window.open(this.href);return false;
2014 Deficient EBV-specific B-and T-cell response in patients with chronic fatigue syndrome Madlen Loebel, Kristin Strohschein, Carolin Giannini, Uwe Koelsch, Sandra Bauer, Cornelia Doebis, Sybill Thomas, Nadine Unterwalder, Volker von Baehr, Petra Reinke, Michael Knops, Leif G. Hanitsch, Christian Meisel, Hans-Dieter Volk, Carmen Scheibenbogen http://journals.plos.org/plosone/articl ... ne.0085387" onclick="window.open(this.href);return false;
2012 Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis Ekua W Brenu, Mieke L van Driel, Donald Staines, Kevin J Ashton, Sharni L Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra B Ramos, Sonya Marshall-Gradisnik http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464733/" onclick="window.open(this.href);return false;
2011 Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study Øystein Fluge , Ove Bruland, Kristin Risa, Anette Storstein, Einar K. Kristoffersen, Dipak Sapkota, Halvor Næss, Olav Dahl, Harald Nyland, Olav Mella http://journals.plos.org/plosone/articl ... ne.0026358" onclick="window.open(this.href);return false;
2010 Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26 Fletcher MA, Zeng XR, Maher K http://www.ncbi.nlm.nih.gov/pubmed/20520837" onclick="window.open(this.href);return false;
2008 Neuroendocrine and immune network remodeling in chronic fatigue syndrome: an exploratory analysis Fuite J, Susan Vernon, Gordon Broderick
Immunological http://www.ncbi.nlm.nih.gov/pubmed/18775774" onclick="window.open(this.href);return false;
2008 Cytokine Polymorphisms Have a Synergistic Effect on Severity of the Acute Sickness Response to Infection Vollmer‐Conna U, Piraino B, Cameron B http://www.ncbi.nlm.nih.gov/pubmed/18937577" onclick="window.open(this.href);return false;
2007 Postinfective fatigue syndrome is not associated with altered cytokine production Vollmer-Conna U, Cameron B, Pavlovic D http://www.ncbi.nlm.nih.gov/pubmed/17712757" onclick="window.open(this.href);return false;
2006 A first study of cytokine genomic polymorphisms in CFS: positive association of TNF‐857 and IFNgamma 874 rare alleles Carlo‐Stella N, Badulli C, De S
Immunological http://www.ncbi.nlm.nih.gov/pubmed/16762155" onclick="window.open(this.href);return false;
2005 Association of chronic fatigue syndrome with human leucocyte antigen class II alleles Smith J, Fritz EL, Jonathan Kerr http://www.ncbi.nlm.nih.gov/pubmed/16049290" onclick="window.open(this.href);return false;
Metabolic
2014 Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO2peak indicates functional impairment Betsy Keller, John Pryor, Ludovic Giloteaux http://www.ncbi.nlm.nih.gov/pubmed/24755065" onclick="window.open(this.href);return false;
2012 Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls AT White, Alan Light, RW Hughen, TA Vanhaitsma, Kathleen Light http://www.ncbi.nlm.nih.gov/pubmed/22210239" onclick="window.open(this.href);return false;
2009 Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects Alan Light, AT White, RW Hughen, Kathleen Light http://www.ncbi.nlm.nih.gov/pubmed/19647494" onclick="window.open(this.href);return false;
Neurological
2015 Right arcuate fasciculus abnormality in chronic fatigue syndrome Michael Zeineh, Kang J, Atlas SW, Raman MM, Reiss AL, Norris JL, Valencia I, Jose Montoya http://www.ncbi.nlm.nih.gov/pubmed/?term=25353054" onclick="window.open(this.href);return false;
2007 Symptoms of autonomic dysfunction in chronic fatigue syndrome Julia Newton, O Okonkwo, K Sutcliffe, Seth A, Shin J, Jones DE http://www.ncbi.nlm.nih.gov/pubmed/17617647" onclick="window.open(this.href);return false;
Treatment
2015 Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome Øystein Fluge, Olav Mella, Loebel M, Grabowski P, Heidecke H, Bauer S, Hanitsch LG, Wittke K, Meisel C, Reinke P, Volk HD, Carmen Scheibenbogen http://www.ncbi.nlm.nih.gov/m/pubmed/26399744/" onclick="window.open(this.href);return false;
2015 B-Lymphocyte Depletion in Myalgic Encephalopathy/ Chronic Fatigue Syndrome. An Open-Label Phase II Study with Rituximab Maintenance Treatment Øystein Fluge, Olav Mella, Risa K, Lunde S, Alme K, Rekeland IG, Sapkota D, Kristoffersen EK, Sørland K, Bruland O, Dahl O http://www.ncbi.nlm.nih.gov/m/pubmed/26132314/" onclick="window.open(this.href);return false;
2013 Altered functional B cell subset populations in patients with chronic fatigue syndrome compared to healthy controls Amolak Bansal, AS Bradley, B Ford http://www.ncbi.nlm.nih.gov/m/pubmed/23480187/" onclick="window.open(this.href);return false;
2013 Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study Jarred Younger, Sean Mackey http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891387/" onclick="window.open(this.href);return false;
2011 Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study Øystein Fluge, Olav Mella, Bruland O, Risa K, Storstein A, Kristoffersen EK, Sapkota D, Næss H, Dahl O, Nyland http://www.ncbi.nlm.nih.gov/m/pubmed/22039471/" onclick="window.open(this.href);return false;
2010 Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels Younger J, Noor N, McCue R, Mackey S http://www.ncbi.nlm.nih.gov/pubmed/23359310" onclick="window.open(this.href);return false;
2009 Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series Øystein Fluge, Olav Mella http://www.ncbi.nlm.nih.gov/m/pubmed/19566965/" onclick="window.open(this.href);return false;
Psychological
2011 The PACE trial Peter White, KA Goldsmith, AL Johnson, L Potts, R Walwyn, JC DeCesare, HL Baber, M Burgess, LV Clark, DL Cox, Jessica Bavinton, BJ Angus, Gabrielle Murphy, M Murphy, H O'Dowd, D Wilks, P McCrone, Trudie Chalder, Michael Sharpe http://me-pedia.org/wiki/PACE_trial" onclick="window.open(this.href);return false;
2005 The Placebo Response in the Treatment of Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis Hyong Jin Cho, Matthew Hotopf, Simon Wessely Found that the placebo response was actually lower in CFS patients
http://simonwessely.com/Downloads/Publi ... FS/176.pdf" onclick="window.open(this.href);return false;