La opinión del Dr. Enlander sobre la investigación del XMRV

[elipoarch]

[t]Dr Enlander's view on XMRV research[/t]

I was asked to comment on the XMRV research.

In Oct 2009 a virtually unknown Institute in Reno, Nevada, the Whitmore Peterson Institute, published in Science exciting research in which they claimed to have discovered a new relationship between the XMRV virus and CFS/ME.

This was exciting news, we hoped it was the initial foundation of proof, that CFS/ME was a physical disease.

Within 6-8 weeks, miraculously, papers were in publication denying the original research. Usually it takes my Medical Center several weeks to allow a research proposal to proceed, followed by several weeks or months for the research to be completed and then several weeks or months for journal acceptance and publication. So I was astounded, as were others, at the time frame of the response, the journals and the relationships of the publishing research centers.

Then a virtual boxing match occurred. This was to the detriment of all. One institute claimed poor cohort selection, another bad specimen handling, another claim related to lab contamination , stale samples that were stored for years, one even blamed the Chinese company that made the specimen tubes and so the complaints and cross complaints mounted.

Harvey Alter, a research physician at NIH of ultimate repute, showed that indeed there was a MLV virus in CFS/ME specimens. This was countered by statement that MLV did not replicate the XMRV virus research. In essence this is true but the MLV virus and the XMRV virus has similar virion particles and/or cross reaction. Instead of certain research workers blasting this difference, it would have been opportune to investigate the relevance of the presence of either of these virions.

Both the protagonists and antagonists are not flawless. The initial research was not replicated in a double blind, multiple lab replicate study by independent selection.

I offered, Whitmore Peterson, an independent replicate study of carefully selected Fukuda/Canadian criteria patients and controls between five viral labs. They were not interested. The whole matter of this research is puzzling, agenda seems to overpower the research . All of us would love to initiate treatment, if indeed the virus was causal and if the treatment neutralized the virus. Lab research into non toxic neutralization in cell culture is incomplete and must be performed prior to using toxic anti-retrovirus treatment in patients. Action against XMRV should be explored in vitro of existing non toxic anti-CFS/ME methods viz; Ampligen, Kutapressin, Nexavir, Hepapressin, isoprinosin etc.

In future I hope to see a united effort in exploring this devastating disease rather than a continuous boxing match

[Tortuga]

Gracias por bajar el artículo.
Así se escribe la Historia. Cuántos "combates de boxeo", cuántos intereses encontrados y cuántas confrontaciones se han cargado el progreso. Lo mismo ocurre en el campo de la investigación sobre el SFC, ... para nuestra desgracia.

[tormenta]

Cuanta esperanza tenemos depositada en estas personas y que triste que los derechos los tengamos que conseguir en combates de boxeo.

Buenas noches.