Disfunción cognitiva en adolescentes con sínd.Fatiga Crónica

[elipoarch]

Aunque en el resumen que he copiado se habla de fatiga crónica, el artículo completo habla de Síndrome de Fatiga Crónica en Adolescentes, como se puede comprobar siguiendo el enlace al artículo
http://adc.bmj.com/content/early/2015/0 ... 06764.long" onclick="window.open(this.href);return false;

[t]Cognitive dysfunction in adolescents with chronic fatigue: a cross-sectional study[/t]
Dag Sulheim1,2, Even Fagermoen3,4, Øyvind Stople Sivertsen5, Anette Winger6, Vegard Bruun Wyller1,7,8, Merete Glenne Øie9,10

+ Author Affiliations
1Department of Paediatrics, Oslo University Hospital, Oslo, Norway 2Department of Paediatrics, Innlandet Hospital Trust, Lillehammer, Norway 3Medical Faculty, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4Department of Anesthesiology and Critical Care, Oslo University Hospital, Oslo, Norway 5Medical Faculty, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway 6Medical Faculty, Institute of Nursing Sciences, Oslo and Akershus University College of Applied Sciences, Norway and Institute of Clinical Medicine, University of Oslo, Oslo, Norway 7Division of Medicine and Laboratory Sciences, Medical Faculty, University of Oslo, Oslo, Norway 8Department of Paediatrics, Akershus University Hospital, Nordbyhagen, Norway 9Innlandet Hospital Trust, Lillehammer, Norway 10Institute of Psychology, University of Oslo, Oslo, Norway
Correspondence to Dr Dag Sulheim, Department of Paediatrics, Innlandet Hospital Trust, Anders Sandvigsgate 17, Lillehammer N-2609, Norway; [email protected]

Published Online First 19 March 2015

Abstract

Objective To compare cognitive function in adolescents with chronic fatigue with cognitive function in healthy controls (HC).

Study design Cross-sectional study.

Setting Paediatric department at Oslo University Hospital, Norway.

Participants 120 adolescents with chronic fatigue (average age 15.4 years; range 12–18) and 39 HC (average age 15.2 years; range 12–18).

Methods The adolescents completed a neurocognitive test battery measuring processing speed, working memory, cognitive inhibition, cognitive flexibility, verbal learning and verbal memory, and questionnaires addressing demographic data, depression symptoms, anxiety traits, fatigue and sleep problems. Parents completed the Behaviour Rating Inventory of Executive Function (BRIEF), which measures the everyday executive functions of children.

Results Adolescents with chronic fatigue had impaired cognitive function compared to HC regarding processing speed (mean difference 3.3, 95% CI 1.1 to 5.5, p=0.003), working memory (−2.4, −3.7 to −1.1, p<0.001), cognitive inhibition response time (6.2, 0.8 to 11.7, p=0.025) and verbal learning (−1.7, −3.2 to −0.3, p=0.022). The BRIEF results indicated that everyday executive functions were significantly worse in the chronic fatigue group compared to the HC (11.2, 8.2 to 14.3, p<0.001). Group differences remained largely unaffected when adjusted for symptoms of depression, anxiety traits and sleep problems.

Conclusions Adolescents with chronic fatigue had impaired cognitive function of clinical relevance, measured by objective cognitive tests, in comparison to HC. Working memory and processing speed may represent core difficulties.