Nuevo Estudio Genético En Fibromialgia

[Náufrago]

Estudio sueco que asocia la Fibromialgia con una variación genética relacionada con una mayor actividad de las células gliales, en un 50% de l@s pacientes. Los mecanismos cerebrales afectados por esta variación genética, además, están asociados con un estado de "hypervigilancia".

The translocator protein gene is associated with symptom severity and cerebral pain processing in fibromyalgia.
Kosek E1, Martinsen S2, Gerdle B3, Mannerkorpi K4, Löfgren M5, Bileviciute-Ljungar I6, Fransson P7, Schalling M8, Ingvar M9, Ernberg M10, Jensen KB11.

Abstract
The translocator protein (TSPO) is upregulated during glia activation in chronic pain patients. TSPO constitutes the rate-limiting step in neurosteroid synthesis, thus modulating synaptic transmission. Related serotonergic mechanisms influence if pro- or anti-nociceptive neurosteroids are produced. This study investigated the effects of a functional genetic polymorphism regulating the binding affinity to the TSPO, thus affecting symptom severity and cerebral pain processing in fibromyalgia patients. Gene-to-gene interactions with a functional polymorphism of the serotonin transporter gene were assessed. Fibromyalgia patients (n=126) were genotyped regarding the polymorphisms of the TSPO (rs6971) and the serotonin transporter (5-HTTLPR/rs25531). Functional magnetic resonance imaging (n=24) was used to study brain activation during individually calibrated pressure pain. Compared to mixed/low TSPO affinity binders, the high TSPO affinity binders rated more severe pain (p=0.016) and fibromyalgia symptoms (p=0.02). A significant interaction was found between the TSPO and the serotonin transporter polymorphisms regarding pain severity (p<0.0001). Functional connectivity analyses revealed that the TSPO high affinity binding group had more pronounced pain-evoked functional connectivity in the right frontoparietal network, between the dorsolateral prefrontal area and the parietal cortex. In conclusion, fibromyalgia patients with the TSPO high affinity binding genotype reported a higher pain intensity and more severe fibromyalgia symptoms compared to mixed/low affinity binders, and this was modulated by interaction with the serotonin transporter gene. To our knowledge this is the first evidence of functional genetic polymorphisms affecting pain severity in FM and our findings are in line with proposed glia-related mechanisms. Furthermore, the functional magnetic resonance findings indicated an effect of translocator protein on the affective-motivational components of pain perception.

https://www.ncbi.nlm.nih.gov/pubmed/27448744" onclick="window.open(this.href);return false;

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Enlace al artículo sobre el estudio de Cort Johnson:

http://www.healthrising.org/blog/2016/1 ... romyalgia/" onclick="window.open(this.href);return false;